This venture brings Binghamton University faculty and other partners together to conduct academic and clinical research in areas such as biomedical research — particularly neurosciences — and computer science. Research applications include studies of the human brain, which will deepen a scientific understanding of brain disorders, from Alzheimer’s disease to autism.

It also enables UHS to offer cutting-edge clinical diagnostics for its patients. Clinical applications of the scanner include diagnosis of brain disease and disorders, cardiovascular disease and orthopedic injuries. It will also offer the capability for patients to receive cardiac MRIs locally, rather than traveling to larger cities such as Syracuse, Rochester and New York City.

“As the two largest employers in the region, UHS and Binghamton University have a history of working together to serve and invest in the community,” says John M. Carrigg, president and chief executive officer of UHS. “This partnership between UHS and BU, and specifically this scanner, will open new avenues of research for faculty and provide UHS physicians and patients with the latest advanced diagnostic imaging technology available in the industry.”

MRI-centered research is a cross-disciplinary pursuit that blends expertise in physics, anatomy, physiology, neuroscience and advanced data processing sciences. The center will enable faculty to expand on cross-disciplinary collaborations and work with UHS physicians to address new research questions that MRI technology can answer.

“This public-private partnership will benefit the community by providing the most advanced imaging technology in the region,” University President Harvey Stenger says. “This project is in alignment with the research strategy outlined by New York Gov. Kathy Hochul in her latest State of the State message, and will enhance our ability to attract external funding, as well as build research partnerships with industry and other universities.”

Binghamton University’s Brain and Body Imaging Research Center was established in 2021 in partnership with UHS and is led by Binghamton Professor of Psychology J. David Jentsch.

“About 50 years ago, MRI was invented by SUNY researchers,” Jentsch says. “Today, we’re bringing a 21st-century version of the technology to the Southern Tier. It will have a transformative impact on our ability to make scientific discoveries that advance human health and to offer the most sophisticated training opportunities to Binghamton students.”

The center will make both organizations more competitive in attracting and retaining research-active faculty and physicians. It also represents a new avenue to kindle collaborations between Binghamton faculty and UHS physicians working on research projects that advance the understanding of human health.

Junior Alejandro Wiltshire has been interested in conducting research for as long as he can remember. Now he works in the Biological Soft Matter Mechanics Laboratory (BSMM) with Guy German, associate professor of biomedical engineering.

“I think of it as a skin lab, even though it’s more than just that,” Wiltshire says. “It’s a very versatile biomedical engineering lab. Most of the time when people think of biomedical engineering, they think of cells or creating some sort of vaccine, whereas this is the more mechanical aspect of it. It’s a great place to learn about skin and to learn about a different aspect of mechanical engineering.”

Wiltshire joined the lab his freshman year. With German’s guidance, he has refined his skills in research and laboratory methods.

“Alejandro is committed, rigorous, and an asset to my team,” German says. “He has integrated well with my team of graduates and undergraduates, has learned the varied techniques required for his research quickly and efficiently, and has shown me he can perform effectively independently and as part of a team.”

Wiltshire is part of two research projects. His work on the rate of infection resulting from surgical sites has broad implications in helping regions of the world where infection rates are higher than average.

“If we can figure out how bacteria enters wounds, we can hopefully prevent this from happening,” Wiltshire says. “We are hoping that through this research, we can actually improve the pre-operative procedures, in order to lower the rate of surgical site infections.”

Wiltshire examines the rate of bacterial infection by making observations through imitation. Using a powerful microscope, Wiltshire shared images of his biomechanical model in detail. A substrate plays the role of the skin, while fluorescent beads mimic bacteria.

He included visuals in the demonstration, which allowed for a deeper, more comprehensive understanding of his investigation.

“I think a lot of science is visuals, like you need to see it in order to understand it,” he says. “I’m more of a visual learner myself, so I like to show things and explain along the way.”

Wiltshire’s second project relates to wrinkle formation as a result of aging. Using a series of complicated instruments, Wiltshire works to determine the individual mechanical and structural properties of skin and how this relates to the formation of wrinkles.

The experiments use skin samples from human cadavers. Within four to six days, members of the lab conduct rigorous experimentation on the samples to gain a better understanding of how wrinkles develop over time and how collagen fibers in the skin alter the shape of the wrinkles.

As a member of an artistic family, Wiltshire knew his interests differed greatly from the people around him, but that didn’t deter him from finding a balance between his love for engineering and his appreciation for art.

“I try to take everything in my life and tie it together,” says Wiltshire, who grew up in Hempstead on Long Island. “I think my purpose was kind of trying to tie the things that I enjoy in science and STEM with the artsy side of my life and the things that I view as being artsy.”

Through his position as the STEAM chair of the Binghamton Art Club, Wiltshire hopes to bring awareness to the intersection of art and engineering, and encourage students to pursue and enjoy both paths.

Wiltshire says his experiences in the lab, including a project as part of the Summer Scholars and Artists Program in 2022, have improved his understanding of complex concepts in his undergraduate engineering classes.

“I’m not a classroom learner, I’m more of a hands-on learner,” he says. “So I’ve realized that the more time I spend in the lab, the more that I actually learn here and that I can apply it to the classroom as opposed to the other way around.”

Wiltshire hopes to pursue a doctorate in biomedical engineering at Binghamton after he graduates.

“I’m always investigating something that I didn’t know before,” he says, “and that, to me, is what I want to do.”

Biophysical chemist Christof Grewer is part of an eight-year collaborative project backed by a $2.4 million National Institutes of Health grant, awarded to the Icahn School of Medicine at Mount Sinai and recently renewed until 2023.

Grewer is a professor of chemistry and the department’s undergraduate program chair. He’s also one of the world’s leading researchers of glutamine, an amino acid found naturally in the body that’s critical for a healthy immune system, and ASCT2, a glutamine transporter, or the “elevator” that carries the amino acid into cells to aid in the production of proteins.

“Cancer cells become addicted to glutamine as an energy source and they import it at a very high rate, so the idea is to target and prevent the glutamine from getting to the cancer cells,” Grewer says.

Avner Schlessinger, a computational biologist and associate professor of pharmacological sciences at Mount Sinai, partnered with Grewer to develop ASCT2 inhibitors. Grewer’s lab creates compounds and oversees functional testing, while Schlessinger’s lab conducts computational analysis and predictions.

“I wanted to collaborate with Christof because he is a top expert in the world in membrane transport biophysics,” Schlessinger says. “I knew I could learn from him and work with him to test both our hypotheses. It’s an ideal collaboration because we complement each other. He is kind and patient in sharing his data and knowledge, which enables us to do better science and really have fun while doing it.”

Grewer and Schlessinger first met during a 2012 conference in Switzerland. Grewer had already established himself as an expert in membrane proteins. During his post-doctoral fellowship at Cornell University in the mid-’90s, he studied glutamate receptors — glutamate is a neurotransmitter and an important molecule in cellular metabolism — and he became a pioneer in using lasers in his research.

After seeing the similar molecular structures in glutamate and glutamine transporters and studying how glutamate transporters responded to blockers, Grewer turned his focus in 2004 to glutamine and an ASCT2 inhibitor. To date, only a handful of labs in the world are involved in similar research.

Grewer and Schlessinger published a pre-print that includes a cryo-electron microscopy structure of ASCT2 and included one of their compounds. Three of Grewer’s doctoral students have assisted in the project; Elias Ndaru was included as a pre-print author due to his instrumental and prolific work in developing compounds.

The compound synthesis and the patent application filing are only the beginning of a long research and development journey. The steps toward potential clinical applications will involve developing the next generation of compounds at ideal potency levels, extensive pre-clinical testing for efficacy and safety, and eventually clinical trials, which will require additional research and development, funding and commercialization partners, such as startups or pharmaceutical companies.

The public tends to think of cancer as one disease when in reality it’s hundreds of different diseases, Grewer says.

“We’re learning every cancer is different and there is not going to be one silver bullet to ‘cure cancer,’” he says. “There are so many molecular aspects and so many different types of tissue involved that treatment may some day be individualized to the patient.”

Grewer has been teaching at Binghamton since 2008 and is thankful to be able work with students while continuing his research. “It’s a nice balance to be in the classroom and to be able to be in the lab,” he says. “It helps me keep up with the latest technologies and developments, and I think my students benefit from that type of experience.”

Laura Cook’s minireview was published in the July edition of the society’s “Infection and Immunity” journal. This was the first time the editorial board used an issue to highlight some of the “brightest early-career scientists who embody the future of research on host-microbe interaction.”

The piece, titled “Two-Component Signal Transduction Systems in the Human Pathogen Streptococcus agalactiae,” was co-authored by Lamar S. Thomas, a doctoral candidate in Cook’s lab.

“We only had two months to put together the review, citing 100 different sources, so it was a lot of reading and work,” says Cook, an assistant professor of biological sciences who joined the Binghamton faculty in fall 2018. “I wanted Lamar to help me because it’s good for her career. I was impressed with how much work she put into it, considering the short timelines.”

Cook’s research focuses on Streptococcus pyogenes, a bacteria that causes strep throat and skin and soft tissue diseases like impetigo and cellulitis. She also studies Streptococcus agalactiae, which commonly live in the gastrointestinal and genital tracts but can cause invasive infection in newborns, maternal women and older individuals with underlying chronic conditions.

“It’s not ideal that the only and best course of treatment is antibiotics,” Cook says. “We’re working toward identifying new treatment strategies. We hope our research moves in the direction of identifying new vaccine candidates.”

Cook did her undergraduate and graduate work at the University of Minnesota. Her post-doctoral studies took her to the University of Illinois at Chicago, where she focused on quorum sensing (the ability to detect and respond to cell population density by gene regulation) in streptococci and the role of cell-to-cell signaling as they colonize the host.

While working in the lab of Michael Federle, she began using animal models of bacterial growth, and her use of a mouse model of vaginal colonization developed into her current research.

Cook, Thomas and several undergraduate students are studying how streptococci grow and interact on mucosal surfaces in the vaginal tract and nasopharynx of mouse models.

Federle said he appreciated Cook’s coordination of his group of bacteriologists with a group with physicians at another university, both of which were researching reoccurring strep throat diagnoses among adolescent patients. The two groups were looking at relevant questions that could be asked in a clinical setting and were researching therapeutic options outside of antibiotics.

“She was really good at finding collaborators and teams of scientists that can work together,” Federle says. “That’s one of the biggest impacts that she’s going to have at Binghamton University.”

Another strength is Cook’s approachability and innate ability to make people — especially students — comfortable. “She’s a good person to collaborate with because she takes on big goals and ideas and she takes them on with ease,” Federle says. “She asks the right questions — questions that are going to need collaboration through interdisciplinary work.”

“Not only does the SUNY system provide quality, affordable higher education opportunities to New Yorkers, but it is also an engine of research and development to increase innovation and grow our economy in New York State,” Cuomo said. “The projects receiving awards today showcase a wide range of areas being explored in campuses across the SUNY system, and they all have potential to leave a positive and lasting impact on our health, environment and society.”

“The broad range of SUNY’s scientific research is reflected in these awards and we will continue to incentivize cross-campus collaboration to promote the strength of working together as a system,” SUNY Chancellor Nancy L. Zimpher said.

“We’re pleased that three Binghamton University projects have received funding through this competitive program,” Binghamton Vice President for Research Bahgat Sammakia said. “The funded projects highlight the strengths our researchers have in the health sciences, focusing on the treatment of stress, stroke prevention and medical imaging to aid in diagnostics and healthcare. These scholars and their collaborative research with other SUNY institutions will have a positive impact on the quality, availability and affordability of American healthcare.”

The Binghamton projects are:

• Stress treatment: This project conducted by Richard E. Mattson, Matthew D. Johnson and Nicole Cameron from Binghamton University, in collaboration with researchers from Upstate Medical University and Stony Brook University, aims to develop an integrative genetic, developmental and psychosocial framework that links social support and improved health outcomes in order to develop treatments that target the negative consequences of stress.
• Medical imaging: Binghamton’s Chuan-Jian Zhong and a collaborator from SUNY Potsdam aim to develop a fundamental understanding of functional nanoprobes for detection of DNAs to aid in diagnostics and healthcare.
• Stroke prevention: Chun-An Chou from Binghamton University and a colleague at Upstate Medical University aim to develop a tool to help doctors make more informed medical decisions by predicting possible aneurism ruptures, which often cause strokes.

Among other funded initiatives are projects that seek to improve cancer detection and treatment and analyze the effects of climate change.

“The scope, scale and diversity of SUNY’s research portfolio are on full display with the announcement of these awards,” said Tim Killeen, president of the Research Foundation for SUNY and SUNY’s vice chancellor for research. “Collaborative research invites industry interest and entrepreneurial opportunity that lead to innovation, new business, jobs and public benefit.”

The SUNY Research Collaboration Fund supports collaboration among researchers and students across SUNY’s campuses in order to enhance the collective impact of their work and ability to advance science, innovation and economic prosperity in New York State.

This second annual round of Research Collaboration Fund awards attracted 77 proposals. Funded projects were selected through a peer-review process. Factors considered in the evaluation included: originality and significance of the research; student involvement; industry and other outreach efforts; and the ability to attract future federal, state, philanthropic or private funding.